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It uses diindolylmethane to block estrogen, which is standard practice, but it uses some unconventional compounds to boost testosterone and to control cortisol levels as well, though the latter is not common in most men's bodies. These hormones, among other things, determine how much muscle mass men should be able to gain, where muscle growth should begin and end, and can trigger or delay aging. When cortisol levels are low, men will often have low testosterone levels and appear weak, and their muscles will be much smaller. While the underlying physiology of the hormone may be similar to men's natural hormone production during exercise, it is believed that women's cortisol levels are largely based on cortisol production by other hormones like estrogen or prolactin – which has a longer half-life. In an accompanying editorial, Dr. Jennifer A. Lohse, a post-doctoral fellow in the Division of Endocrinology at the University of Pennsylvania, and Dr. Jeffrey W. Stoller, chair of the Endocrinology Department Department of Medicine at New York University, write in the journal Cell Metabolism, "Because the cortisol pathway is involved in many aspects of human biology, it is vital to provide the most relevant information possible at any time." In the journal Molecular Endocrinology 2014 oncology research and drug development, researchers from Harvard University and St. John's University in Canada wrote in their article, "Inhibition of cyclooxygenase activity in human female breast cancer cells results in inhibition of tumorigenesis in a dose-dependent manner." It is important to note that the hormonal regulation of muscle growth is a complex phenomenon that is influenced by many factors, including genetics, diet, exercise and even environmental factors. As such, no single intervention will have a dramatic effect on muscle growth until studies can pinpoint the reasons for the decline. This will require further study to determine why cortisol and other hormones decrease with aging, but it is unlikely that this research will result in any dramatic breakthroughs anytime soon for most men – though more studies need to be done. A more recent study, published in June in the journal Applied Physiology, Nutrition and Metabolism, explored whether testosterone was an effective way to increase muscle in older men with very low testosterone levels. It noted a "low" cortisol level was associated with "low" testosterone in men age 35-60, but this relationship disappeared in older men who had high levels of cortisol. This is an interesting finding because cortisol is considered a "stress hormone" that plays a large role in energy balance, mood, and the immune system. There are numerous studies demonstrating Related Article: